The most populated city in the Pacific Northwest region of North America and the U.S. state of Washington is Seattle. With 780,995 residents as of 2024, it ranks as the 18th most populated city in the US. However, with more than 4.15 million inhabitants, the Seattle metropolitan region ranks as the 15th most populated metropolitan area in the US. King County, Washington's most populated the county, has its county seat in the city. Seattle was one of the fastest-growing big cities in the nation, with a growth rate of 21.1% between 2010 and 2020. Seattle is located on an isthmus that separates Lake Washington from Puget Sound, a Pacific Ocean inlet. Situated roughly 100 miles (160 km) south of the Canadian border, it is the northernmost major city in the United States. As of 2021, the Port of Seattle, which serves as a gateway for trade with East Asia, ranked fourth in North America for container handling. Before the first permanent European settlers arrived, Native Americans (including the Duwamish, who had at least 17 communities surrounding Elliot Bay) had lived in the Seattle area for at least 4,000 years.14 On November 13, 1851, Arthur A. Denny and his party of travelers—later dubbed the Denny Party—arrived at Alki Point on the schooner Exact from Illinois via Portland, Oregon.Named ""Seattle"" for Chief Seattle, a notable 19th-century chief of the nearby Duwamish and Suquamish tribes, the settlement was relocated to Elliott Bay's eastern side in 1852.

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